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Breakthrough Biology

ERA Biotech has developed the Zera family of assembler peptides that trigger the in vivo formation of StorPro™ designed storage organelles.

Proteins of interest fused to Zera are stable, functional and highly concentrated in StorPro organelles whose high density facilitates simple recovery with minimal chromatography.

Zera assembler peptides bring a unique combination of encapsulated, inclusion body-like expression with eukaryotic folding, assembly and processing:

• enable difficult-to-express and poorly/non-secreted proteins
• high pre-purification titers in established non-bacterial production hosts.

This technology utilizes the same mechanism used by seeds to stabilize and accumulate storage proteins and is the preferred choice for expression of proteins that are toxic, labile or refractory to secretion. In addition, the properties of StorPro organelles create unique product and delivery options.

ERA’s technologies work in a variety of mammalian, insect and plant cell culture systems, and in plant and animal transgenics. StorPro encapsulation insulates the product from the cell’s protein-modifying and proteolytic machinery.

ERA-enabled product opportunities under investigation include biodrugs, oral and injectable vaccines, highly potent enzymes for bioenergy applications, and other protein-based prospects in the health, industrial and nutrition sectors.

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