Product name

Chitinosanase - new enzymes allows purification of defined, individual oligomers

Summary

Novel chitosan-cleaving enzyme with defined specificity for the production of chitosan-oligomers

Organization name

Provendis

Profile

Chitosan is a linear co-polymer of glucosamine (D) and Nacetyl-glucosamine (A) units. Enzymatic degradation of this co-polymer by chitinases or chitosanases leads to heterogeneous mixtures of oligomers, depending on the cleaving specificity of the enzyme used.

The invention provides a novel chitosan-cleaving enzyme with a strict specificity for cleavage of the sequence AD. This novel enzyme is named chitinosanase. Examples of degradation products illustrate the effect. 1) chitosan example, 2-4) relevant degradation products: 2) chitinase AA; 3) chitosanase DD; 4) chitinosanase AD

1) DDDAADDDADAADAAADDAADDAAADDADDDA
2) DDDA ADDDADA ADA A ADDA ADDA A ADDADDDA
3) D D DAAD D DADAADAAAD DAAD DAAAD DAD D DA
4) DDDAA DDDA DAA DAAA DDAA DDAAA DDA DDDA

This novel chitinosanase leads to oligomers with blocks of D-residues at the non-reducing end and blocks of A-residues at the reducing end. This blockwise distribution of the acetyl residues greatly simplifies purification of defined, individual oligomers. The invention provides the production and purification processes for the enzyme.

Current status

We offer a research collaboration with licensing option. Information about the patent situation will be provided on request.

Contact

Dr. Solveig Nicole Söding
Tel: +49 208 94 105 35
so(at)provendis.info 

About PROvendis GmbH

PROvendis offers companies certified and patented innovations from 24 North Rhine-Westphalian universities. The core function of the enterprise is to market patentable and commercially exploitable inventions. PROvendis GmbH was founded in 2001 as a wholly owned subsidiary of Zenit GmbH, a management consultancy firm in cooperation with the state of North Rhine-Westphalia. Since January of 2002, PROvendis has been the service provider for the universities of the state of North Rhine-Westphalia. Within the scope of the BMBF commercialization campaign, the Federal Ministry for Education and Research (BMBF) supports the activities of PROvendis.

Description File

 061008_1665_Chitinosanase4cd37f75.pdf

URL

http://www.lifesciencepatente-nrw.de

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