Product name
Novel Pharmaceutical Compounds against MalariaSummary
Isoquinoline alkaloids isolated from marine and terrestrial organismsOrganization name
IMG Innovations-Management GmbHProfile
Several isoquinoline alkaloids with interesting, pharmaceutically useful properties have recently been isolated from marine as well as terrestrial organisms. They served as models for 3,3-dimethyl-8-oxo-di-(or: tetra-)hydroisoquinolines, a compound class which is easily accessible by total synthesis and for which pronounced activities against protozoae have been found in cell vitality assays.
Advantages
- Simple synthetic procedure giving high yield; compatible with various substitution patterns and therefore appropriate for the synthesis of larger compound libraries
- High in vitro activity of the lead structure (IC50 = 32 nM)
- Significant specificity against selected protozoae; almost immeasurable cytotoxicity toward mammalian cells
- Partially additional activity against leishmaniasis or antiviral activity (for plasmodial secondary infection as a result of low immunity, e.g. after HIV primary infection)
- Expectedly good "drug likeness" due to structural analogy with low-molecular-weight natural compounds
Stage of Development
- Scalable procedure to chemically synthesise the pharmaceutical agents
- Quantitative structure-activity profiles of a multitude of variously substituted derivatives against infected human erythrocytes
- Molecular modelling-studies with structurally related molecules
A German patent has been granted. The technology if offered by IMG.
Contact
Dr. Andreas Kirschfeld
kirschfeld(at)img-rlp.de
About IMG
The IMG Innovations-Management GmbH is a subsidiary of the Investment and Economic Development Bank of Rhineland-Palatinate GmbH. It offers a multitude of services for the realisation and commercialisation of innovations and inventions including intellectual property protection and license brokerage. It is the primary contact point regarding all matters of technology and knowledge transfer within the German state of Rhineland-Palatinate. Within the framework of the Scientific Patent Network Rhineland-Palatinate it forms the connection between scientists and university administrations and provides universities and research institutions with all prerequisites to bring research results to the market on a fast track. Within the Scientific Patent Network the IMG is the leading service provider offering as a proficient partner a professional intellectual property management to all associated universities and institutions.
Description File
UMZ016_malaria_engl34a6fe9c.pdf
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