Product name
Neuromorph: High throughput automatic reconstruction of neuronal axonal branching patternsSummary
acquiring large numbers of neuronal morphologies and their automatic reconstruction via image processing algorithmsOrganization name
Max-Planck-Innovation GmbHProfile
The reconstruction of the entire axonal arbor of a pyramidal neuron is a challenging task in neuroscience.
NEUROMORPH is a fast and reliable automatic method for tracing axonal morphologies, based on the latest bright-field imaging technology and novel image-processing algorithms.
The system images large areas of the brain, covering almost the complete axonal projection domain of a pyramidal neuron, by using the recently developed mosaic scanning technology. Three-dimensional images of neuronal structures are acquired by a high modulation optical sectioning method, and well-designed algorithms process these images in order to extract neuronal structures.
The conversion of the implicit representation of the voxels (obtained by the optical sectioning method, see into an explicit vector representation allows the automatic extraction of the branching structures. In a final processing step, the tracings from single slices are aligned in order to create a complete three-dimensional representation of a neuron.
Advantages
This technique allows acquiring large numbers of neuronal morphologies and their automatic reconstruction via image processing algorithms. The reconstruction of a 3D neuron structure is usually 100 times faster than that obtained with conventional methods.
PCT patent application was filed.
Contact
Max-Planck-Innovation GmbH
Priv.-Doz. Dr. Wolfgang Tröger
troeger@max-planck-innovation.de
About Max-Planck-Innovation GmbH
Max Planck Innovation advises and supports scientists of the Max Planck Society in evaluating inventions and filing patent applications. They market patents and technologies to industry and coach founders of new companies based on research results from Max Planck Institutes. Every year, they evaluate about 130 inventions, of which 80 to 100 lead to the filing of a patent. In the last five years alone, they advised 28 spin-offs, closed more than 450 license deals and generated proceeds of more than EUR100m for inventors, institutes and the Max Planck Society. As a result, Max Planck Innovation is among the world's most successful technology transfer organizations. Max Planck Innovation was founded in 1970 as Garching Instrumente GmbH and operated under the name of Garching Innovation from 1993 to 2006.
Description File
0105-3628_GWT_DE_01.pdf
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