Product name
Porphyrin derivatives as photosensitizer in photodynamic therapySummary
Cyclo-keto-tetraphenylporphyrins are second generation photosensitizer for use in photodynamic therapy.Organization name
ipal GmbHProfile
These porphyrins are advantageous
- in their good producibility,
- in their relatively favourable solubility in organic as well as aqueous solutions and
- in their absorption beyond the absorption range of blood.
By suitable substitution of the functional groups and / or coupling to respective carrier molecules, the target specificity of the substances in the living organism can be enhanced. Some members of the mentioned molecule family demonstrated a triplett quantum yield of approx. 95% and a singulett oxygen quantum yield of approx. 90%, thus showing superiority to all presently known photosensitizers (usual quantum yields around 50%).
Benefits
- Better solubility than other photosensitizers in organic as well as aqueous solutions
- Surprisingly high singlet oxygen quantum yield of 0.9 promises high phototoxic efficacy
- Absorption wavelength is outside the range for blood
- Possibility for chemical coupling to suitable molecular carriers or possibility for substitution of the functional groups may allow target specificity
A European patent application has been filed.
The technology was developed at the Humboldt University (Berlin/Germany) and is offered by IPAL GmbH.
Contact
IPAL GmbH
Dr. Christian Wunsch
christian.wunsch(at)ipal.de
About IPAL
The ipal GmbH patent agency assesses and markets the inventions of scientists in the area of Life Sciences and Physics & Engineering from Charité-Universitätsmedizin (University Medicine), Robert Koch Institute, Deutsches Herzzentrum (German Heart Institute), Bundesanstalt für Materialprüfung (BAM - Federal Institute for Materials Research and Testing), the Zuse Institute as well as the Paul Ehrlich Institute, Langen and the Jacobs University Bremen. IPAL provides all of the services necessary - from the assessment of patentable technologies to a comprehensive patent protection all the way to the evaluation of sales returns potentials on the market and successful commercialisation through the use of licensing agreements.
Description File
PorphyrinDerivatives.pdf
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