Product name
RBL-C5aR Cell LineSummary
A transfectant RBL-C5aR cell line which is able to express more than one million C5a-receptors on its cell surface.Organization name
Georg-August-University GoettingenProfile
The C5a-receptor is a cell surface receptor for C5a, an element of the biochemical cascade of the complement system. C5a is an important chemotactic protein, helping recruit inflammatory cells and has anaphylatoxin activity (mast cell degranulation, increased vascular permeability, smooth muscle contraction).
The C5a-receptor (CD88) is a receptor originally described on neutrophils and monocytes but recently found on hepatocytes, epithelial cells, endothelials and tissue mast cells.
Scientists at the University of Goettingen developed a transfectant RBL-C5aR cell line which is able to express more than one million C5a-receptors on its cell surface, showing a specific high Ca2+ signal.
The generated RBL-cells express C5aR in a number of 'flavours' (FLAG-tagged, Nglycosilation deficient, phosphorylation-deficient, cotransfected with other GFCR). This cell line would make the development of a standardized assay easy, fast, reproducible and sensitive.
MBM ScienceBridge is looking for companies who are interested in licensing, developing and commercializing this approach.
Contact
MBM ScienceBridge GmbH
Dipl.-Biol. Christiane Bolli
cbolli(at)sciencebridge.de
About MBM
MBM ScienceBridge GmbH is the technology transfer organization of the Georg-August University Goettingen. It is a spin-off of the Competence Center MBM, a technology transfer initiative within Georg-August-University formed in 2001, which was spun off into the MBM ScienceBridge GmbH in 2004. Their focus includes innovations from the areas of Medical and Measurement Technology, Biotechnology, Chemistry, Physics, Information Technology, Forestry and Agriculture.
Description File
BioM1051-UMG_RBL-C5b12b265c.pdf
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