Product name
Metal salophen complexesSummary
Metal salophen complexes, especially iron salophen complexes, for treatment of cancerOrganization name
ipal GmbHProfile
Most anti-neoplastic drugs, like Cisplatin, 5-Fluoroacil and Etoposid, induce apoptosis via the tumor suppressive effects of p53. This leads to a higher effetiveness of cytostatics in p53 positiv tumor cells.
Determination of IC50 values revealed a strong cytostatic effect of Fe(II) and Fe(III) salophen complexes in p53 independent breast tumor cells. Activity was 100fold higher compared to known cytostatica.
Application
- Therapy of cancer and metastases like breast, colorectal, lung, gastric, pancreatic and esophagal cancer with metal salophen complexes
A European patent application was filed.
This is an invention of the Free University Berlin, Germany offered by IPAL.
Contact
Dr. Andreas Voigt
andreas.voigt(at)ipal.de
About IPAL
The ipal GmbH patent agency assesses and markets the inventions of scientists in the area of Life Sciences and Physics & Engineering from Charité-Universitätsmedizin (University Medicine), Robert Koch Institute, Deutsches Herzzentrum (German Heart Institute), Bundesanstalt für Materialprüfung (BAM - Federal Institute for Materials Research and Testing), the Zuse Institute as well as the Paul Ehrlich Institute, Langen and the Jacobs University Bremen. IPAL provides all of the services necessary - from the assessment of patentable technologies to a comprehensive patent protection all the way to the evaluation of sales returns potentials on the market and successful commercialisation through the use of licensing agreements.
Description File
06063_salophen.pdf
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