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Name

Compositions for diagnosing cancer (liver cancer/breast cancer)

Organization name

PVA Saarland

Profile

Technical Summary

Compositions for diagnosing cancer (liver cancer/breast cancer) with improved sensitivity and specificity.

  • The present invention relates to a composition for diagnosing liver cancer using an autoimmune antibody (or an antigen-binding site thereof) specifically binding to ATIC.
  • The present invention relates to a composition for diagnosing breast cancer using an autoimmune antibody (or an antigen-binding site thereof) specifically binding to a cytokeratin 8/18 complex.

The present invention is applicable to clinical diagnosis at the current technology level.

Technical Superiority

High substrate sensitivity & specificity

  • Liver cancer may be diagnosed with sensitivity of 87% and specificity of 88%.
  • Breast cancer may be diagnosed with sensitivity of 50% and specificity of 82.61%. Improved ease in production
  • Minimizing molecular weight (size) of a protein ⇒ Presenting an antigen in which only an antigenic site specifically reacting with each antibody is expressed on a carrier protein. Convenience in securing samples & test safety
  • A sample selected from the whole blood, blood plasma, saliva, urine, phlegm, lymphoid fluid, cerebrospinal fluid and intercellular fluid may be used.
  • Test stability and patient’s convenience are secured using a non-invasive method.

Applications

Diagnostic compositions

  • Kits for diagnosing cancer (liver cancer/breast cancer)
  • Drug screening Pharmaceutical compositions
  • Antibody therapeutic agents
  • Drug delivery systems (DDSs)

Please see the flyer for technical data.

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