Technical Summary

• The present invention relates to a novel indole derivative or pharmaceutically available salts thereof, a method of preparing the same and a composition for preventing and treating metabolic diseases such as obesity, diabetes, hyperlipemia, arteriosclerosis and fatty liver, including the indole derivative as an effective component
• The present invention may provide a health food composition for preventing or improving diseases such as obesity, diabetes, hyperlipemia, arteriosclerosis and fatty liver
• Effective therapeutic effects have been confirmed through experiments using a simple animal model

Major Technical Data

Excellent effects of inhibiting DGAT enzymatic activities

• It has been confirmed that the compounds significantly inhibit DGAT enzymatic activities in a concentration-dependent manner.
• It has been confirmed that compounds 15, 27 and 32 have excellent effects of inhibiting DGAT enzymatic activities.
  

Inhibiting the biosynthesis of neutral fat in cells

• DGAT enzymatic activities are measured using human-derived liver cells, HepG2

Toxicity Test

• An Acute Toxicity Test was performedthrough an animal experiment

Technical Superiority

Effects of inhibiting DGAT enzymatic activities

• The biosynthesis of neutral fat is inhibited by inhibiting DGAT associated with the synthesis of neutral fat
• An increase in body weight induced by a high fat diet is suppressed.
• Insulin resistance is improved and insulin sensitivity is enhanced
• Biosynthesis of neutral fat in cells is inhibited.

Stability

• No toxicity was found in experiments using an animal model
• It may be used as a therapeutic agent for treating metabolic diseases since it has no toxicity to human bodies

 Applications

• It may be used as a therapeutic agent for treating metabolic diseases such as obesity, diabetes, hyperlipemia, arteriosclerosis and fatty liver
• It may be formulated into pharmaceutical preparations